This transformation has been carried out numerous times, on 50 mg to 1 g, always achieving excellent yields. Whereas usually the carboxylic acid is mixed with DCC to form the active ester, before addition of the alcohol, this is not possible in this case as the hydroxyl group on the naphthoic acid will result in formation of dimers. Hence, both starting materials are dissolved in THF/DCM before addition of the reagent. Furthermore, it should be noted that these types of transformation usually proceed best in dichloromethane, but had to be carried out in a mixture of THF and DCM, because of limited solubility of the carboxylic acid. The side-product from this reaction, a urea, is partly soluble in aqueous as well as organic phases and thus purification by column chromatography is necessary. This can be avoided by employing alternative, more expensive reagents such as EDC (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, moderate yields) and DIC (diisopropylcarbodiimide, yields almost as high as with DCC).