Building Community for Chemists

About ChemSpider SyntheticPages

ChemSpider SyntheticPages is a freely available interactive database of synthetic chemistry. We publish practical and reliable organic, organometallic and inorganic chemical synthesis, reactions and procedures deposited by synthetic chemists. Synthetic methods on the site are updated continuously by chemists working in academic and industrial research laboratories.

ChemSpider SyntheticPages encourages submissions from graduate students, postdocs, industrialists and academics. Learn more...

Editorial board

Selected ReactionRecent PublicationsMost Popular

Copper catalysed coupling of alkynes and iodoalkynes

zac etheridge

Published:Jul 03 2001

The two alkynes are stirred together at 0C in pyrrolidine and the copper iodide is added in one portion, initially creating a green coloured solution which quickly turns red/brown. The reaction is stirred at this temperature for 30 minutes-1 hour until completion (TLC), then quenched with ammonium chloride solution, extracted 4 times with ether, washed with brine, dreid over magnesium sulphate, filtered and concentrated. Purification is achieved by column chromatography eluting with 20-50% EtOAc/PE.

Thumbnails